Ross County is located in the Appalachian region of southern Ohio and is designated a rural county. The county ranks in the 75th percentile for overdose indicators. The overdose rate in 2018 was 44.84 per 100,000 population, a rate higher than Ohio’s urban counties. Currently, the Ross County Health District (RCHD), via the Hope Partnership Project, is collecting data through an overdose fatality review committee, Peer Recovery Support Center, Post Overdose Response Team (PORT), the local emergency room, and Project DAWN (naloxone distribution) efforts. The RCHD will develop a countywide data-fusion center to better collect, analyze, and communicate data to enhance existing data-driven response efforts through the engagement of additional partners and the employment of a data analyst.